Microscope Case Free

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Posted by kidsEntertainment | Posted in Educational Toys | Posted on 14-05-2010

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Microscope Case Free

Use corrosion microscopic and reduce the performance and life of Pharmaceutical Tablet Compression tools

At first glance, it is almost impossible to detect the microscopic signs of abrasion and corrosion that can reduce the effectiveness of compression tools pharmaceutical tablets. Tools high performance used by pharmaceutical companies in the manufacture of tablets and capsules requires very polished, scratch-free surfaces in order to maintain contact with the area required to compress powder formulation and development of a consistent, quality product. Unfortunately, steels industry standard tools such as the series D, S-series, and stainless steels (408, 440C) are prone to abrasive wear and corrosion. Since the working surfaces of punches and dies rough against wear and corrosion, a series of physical phenomena occur that act to reduce productivity and increase tablets manufacturing costs.

Increased mechanical interlock -

When microscopic scratches and pits on the surfaces develop useful, pharmaceutical powders can trapped in these surface imperfections. As additional tablets are compressed, the powder particles adhere to the surface trapped and begin to build-in the surface. Unfortunately, due to the fact that these imperfections are almost invisible to the human eye, the effects of these scratches and holes are not noticed until it is too later. Finally, paste and choose to appear, and production must be stopped to remove and clean blows. Losses mount manufacturers faster every second that production is online.

Similarly, if the surfaces corrode and useful compressed oxide layers on the surface construction of punch, powders begin to stick to the rough oxide layers. Cleaning with detergents or solvents will remove the dust stuck to, but not to restore the original finish of the floor space. Tools in this condition requires regular polishing and polishing scratches and pits soften and remove the corrosion products on surfaces to return to working conditions. Once Moreover, the production must be stopped to remove and polish the machine tool.

Increased friction between the powder and Punch / Die Surfaces -

Whether due to scratching or corrosion, rough surfaces will also increase the frictional forces as the formula powder flow through the punch faces during compression. Because the production of pharmaceutical tablets is an extremely precise, the slightest imperfection in the process at any level result in an increasing number of new problems on the line. Manufacturers use a predetermined level of the materials have been found to meet the most high levels of efficiency. Once minor surface abrasions begin to appear on the items, levels of lubricants and glidants default will no longer be effective. Forces higher compression may be necessary and the work of projection will increase.

Reduction of Life -

Constant restoration of punch worn and corroded by the faces to polish and polish has a significant negative impact on the life of the tool. contain abrasive polishing compounds really removing layers thin metal surface to polish the scratches and pits waiting. Repeated polishing can reduce the dimensions critical hit in the area of land at the tip of the punch, degradation which fit between the punch and die. Constant polishing also leads to rapid degradation of the aspect ratios of features embossed on the beats. In both cases the useful life of the punch is reduced.

Instead of continuing the cycle of abrasive wear, restoration, and subsequent further degradation, pharmaceutical manufacturers have additional options for maintaining the surface integrity of high performance tools. There a number of different performance coatings available, each with advantages and disadvantages. Some precision metal coatings such as those applied by the coating process IBED be able to protect and improve the tablet usable areas and apply compression at low temperature, thus eliminating the possibility of dimensional distortion tools. The result is an extended and improved the efficiency of compression tools pharmaceutical tablets.

About the Author

Dr. Deutchman is currently Chairman and Director of Research and Development at Beamalloy Technologies, LLC where he is directly involved with the research, development, and application of the Beamalloy patented IBED coating process. He is the author of numerous articles published in a variety of scientific and trade journals, holds numerous patents, and lectures widely on surface engineering.

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